| 摘要 |
A compound of the formula <CHEM> wherein R1 represents a hydrogen atom, a hydroxil group or a methyl group, R2 represents a lower alkyl group or an aralkyl group, substituted or unsubstituted. having 7 to 20 carbon atoms, and X represents a bromine or iodine atom. This compound is prepared by reacting a compound of the formula <CHEM> wherein R1 and R2 are as defined above, and Z represents an amino group or a blocked amino group, with a brominating or iodinating agent selected from the group consisting of N-bromimides, N-bromamides, N-iodimides, N-iodamides und alkali metal iodides. It can be converted into a useful compound having excellent pharmacological activity and having the formula <CHEM> wherein R1 represents a hydrogen atom, n hydroxyl group or a methyl group, R4 represents a lower alkyl group, a hydroxy lower alkyl group, a lower alkoxy-lower alkyl group, a di(lower alkyl)aminolower alkyl group, a lower alkanoyloxy-lower alkyl group, a benzoylamino-lower alkyl group, a cyclohexyl group, a phenyl group, or a 5- or 6-membered |
