| 发明名称 |
DIASTEREOISOMERE TETRAHYDROPYRIDO (2,3-D) PYRIMI- DIN DERIVATIVER |
| 摘要 |
<p>The diastereoisomeric forms of N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d] -pyrimidin-6-yl)ethyl]benzoyl)-L-glutamic acid are antineoplastic agents. The compounds are prepared by separation of the diastereoisomeric form of the correspondingly protected glutamic derivatives and hydrolytic or hydrogenolytic removal of carboxylic acid and/or amino protecting groups.</p> |
| 申请公布号 |
DK232387(A) |
申请公布日期 |
1987.12.07 |
| 申请号 |
DK19870002323 |
申请日期 |
1987.05.06 |
| 申请人 |
TRUSTEES OF PRINCETON UNIVERSITY, THE |
发明人 |
TAYLOR, EDWARD C.;BEARDSLEY, GEORGE PETER;SHIH, CHUAN;FLETCHER, STEPHEN R. |
| 分类号 |
A61K31/505;A61K31/195;A61K31/519;A61P35/00;C07D471/04;(IPC1-7):C07D471/04 |
主分类号 |
A61K31/505 |
| 代理机构 |
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代理人 |
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