2-SUBSTITUTED-AMINO-PYRIMIDIN-4-ONE COMPOUNDS

摘要

The invention relates to a heterocyclic derivative of the formula: where D is O, S or NH; E is CH or when D is O or S, E is N; Y is S, O, CH2, SO or a direct bond; m is 0 to 4 and n is 1 to 4, provided that when Y is S, O or SO m is 1 to 4, and when Y is O or SO, n is 2 to 4; A is C(3-4) chain comprising at least one C and also optionally S, N, 2N or N and S, and also comprising C=O or C=S or where possible SO2 and chain optionally substituted by 1 or 2 C(1-6)alkyl, benzyl, naphthylmethyl, 2-phenethyl, 4-phenylbutyl, pyridylmethyl, thiazolylmethyl, thienylmethyl, benzyloxy, pyridylmethoxy or phenoxymethyl radicals each optionally substituted on the aromatic ring system by 1 to 3 halogen atoms or methyl, methoxy, trifluromethyl, dimethylamino, phenyl or phenoxy radicals; and the salts thereof. The compounds of the invention are histamine H-1-antagonists and inhibit secretion of gastric acids.