| 摘要 |
<p>Process for obtaining sulphonamidines of general formula I". Comprises preparing a compound of formula I" where R" is 2-[[[2-[(aminoiminomethyl)amino]-4- thiazolyl]methyl]thio]ethyl and R"1 is phenyl substituted by halogen, alkoxy carbonyl, dialkylamino, nitro, alkyl sulphonyl, alkyl sulphonyl amino and alkyl thio, and their therapeutically acceptable salts, by reacting an amine of formula II" where R" has the same meaning as in I" with an excess of an orthoformate of formula III in which R2 is alkyl, thus obtaining the intermediate imidate of formula IV", where B" and R2 have the same meanings as in the previous structures, which in turn is caused to react with the sulphonamide of formula V", where R"1 has the same meaning as in I", in an alkanolic medium. Useful for inhibiting acid secretion through antagonism of H-2 histamine receptors. R"-NH-CH=N-SO2-R"1(I") R"-NH2 (II") H-C(OR2)3 (III) R"-N=CH-OR2 (IV") H2N-SO2-R"1 (V")</p> |
