IMIDAZO PYRAZINE AND IMIDAZO PYRIMIDINE DERIVATIVES

摘要

The invention relates to use of compounds of formula (I) wherein n is 1, 2 or 3; m is 0, 1, 2 or 3; any one of A<1>, A<2> and A<3> is nitrogen and the other two are CH; R<1> groups are independently selected from those specified in (a) and (b) below, namely: (a) cyano, hydroxy, groups of formula -S(O)xR<8> in which x is 0, 1 or 2 and R is a C1-4 alkyl group and groups of formula -OR in which R is allyl or a C1-4 alkyl group, which alkyl group is optionally substituted by one or more radicals selected from halo, C1-4 alkoxy and groups of formula -S(O)xR in which x and R are as defined above (b) C1-4 alkanoyl, C1-4 alkanoylamino, 2-methyl-1,3-dioxalan2-yl, sulphamoyl, N-C1-4 alkylsulphamoyl, N, N-di-C1-4 alkylsulphamoyl, C1-4 alkylsulphonyloxy, C1-4 alkylsulphonylamino, aminosulphonyloxy, N-C1-4 alkylaminosulphonyloxy, N,N-di-C1-4 alkylaminosulphonyloxy, ureido, 3-C1-4 alkylureido, 3,3-di-C1-4 alkylureido, aminosulphonylamino, (C1-4 alkylaminosulphonyl)amino, (di-C1-4 alkylaminosulphonyl)animo, carboxy, carboxylic derivatives (selected from carbamoyl, N-C1-4 alkylcarbamoyl, N,N-di-C1-4 alkylcarbamoyl, carboxylic acid halides, C1-4 alkoxycarbonyl, hydroxy-C1-4 alkoxycarbonyl and hydroxymethylene) and groups of formula - OR in which R is a straight or branched aliphatic moiety having 1 to 4 carbon atoms, optionally substituted by one or more radicals independently selected from halo, C1-4 alkoxy and groups of formula - S(O)xR in whixh x and R are as defined above, provided that R is not a group as defined for R above; R<2> is selected from hydrogen, halo, amino, hydroxy, C1-4 alkyl and C1-4 alkoxy; R<3> groups are independently selected from halo, carboxy,. amino C1-4 alkylamino hydroxy, C1-4 alkoxy, hydroxy-C1-4 alkoxy, C1-4 alkylthio and C1-4 alkylsulphonyloxy; provided that when R<2> is hydrogen and either m is 0 or m is 1 and R<3> represents halo, then at least one R<1> group must be selected from (b) above; and physiologically acceptable salts and/or N-oxides thereof, as inotropic agents, and to pharmaceutical formulations containing them.