| 摘要 |
Pyrazolopyridine derivatives of the formula: <IMAGE> wherein R<1> represents a carboxy, alkoxycarbonyl, carbamoyl, alkylcarbamoyl or dialkylcarbamoyl group, R<2> represents a halogen atom or an alkyl, cyano, alkoxycarbonyl, carboxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, nitro, hydroxy, alkoxy, aryloxy, aralkyl, trifluoromethyl, alkylthio, alkylsulphinyl, alkylsulphonyl, arylthio, arylsulphinyl, arylsulphonyl, alkanoyl, aroyl or aryl group, or an amino group which may be substituted by one or two groups selected from alkyl and aryl groups, and n represents 0, 1, 2, 3 or 4, and salts thereof, with the provisos that:- (i) R<1> is alkylcarbamoyl when n is 0, (ii) R<1> is other than a dialkylcarbamoyl group when n is 1 and R<2> is a methyl group, (iii) R<1> is other than a carboxy or ethoxycarbonyl group when n is 1 and R<2> represents a methyl group in the 7-position, and (iv) R<1> is other than dimethylcarbamoyl when (R<1>)n represents a methoxy or tert-butyl group in the 5-position or two methyl groups in the 6-and 7-positions, are new compounds which possess properties indicative of utility in the treatment of arthritic and related autoimmune disorders. <IMAGE> |
