摘要 |
<p>Implants, microbeads and microcapsules suitable for injection into an animal body comprise cross-linked but physically-native albumin and a non-albumin substance, for example a steroid or a non-steroid enzyme. The microcapsules are formed under mild conditions (not above 37oC and pH 4-10) from either a native albumin and a non-denaturing bi-functional cross-linking agent or a self-polymerizable albumin derivative. Previously known techniques for cross-linking albumin cause physical denaturation which renders the albumin immunologically unacceptable. The method may be used to immobilize living cells such as yeast.</p> |