| 摘要 |
<p>NEW MATERIAL:A compound of formula I [R<1> is alkyl, cycloalkyl, cycloalkenyl, or cycloalkadienyl group, etc.; R<2> is H, protective group, or cation; X is O or S; Z is formula II or III (Y is H, halogen, OH, or cyano group)], its salt, or ester. EXAMPLE:7-[ D-alpha-Uracil-1-carbonyl-amino )phenylacetamido ]-3-methyl-3-cephem- 4-carboxylic acid. USE:Antibacterials effective against Gram-positive and Gram-negative bacteria. PROCESS:A penicillin of formula IV or its derivative is reacted with a uracil of formula V or its reactive derivative, e.g. uracil-1-carboxylic acid, in the presence or absence of a base in an inert solvent, e.g. methanol, at -50-80 deg.C to give the compound of formula I, its salt, or ester.</p> |
