| 摘要 |
Provided herein are compounds, compositions, and methods of using them to treat infections, neoplastic disease, inflammatory disease, and pain. Such compounds are nucleotides, acyclonucleotides, and ANP phosphonates conjugated with forms and/or moieties of Vitamin B6 for delivery past the cell membrane and into the cell. |
| 主权项 |
1. A method of ameliorating or treating a viral disease, a neoplastic disease, an inflammatory disease, a parasitic disease, or a disease caused by a bacterial or a fungal infection, the method comprising administering to a subject suffering from the disease a therapeutically effective amount of one or more compounds having the following structure: wherein R1 is substituent derived by removal of the hydrogen from the 5′-O-hydroxyl of a nucleoside or removal of an equivalent hydrogen from an acyclonucleoside; X, Y, and Z are independently O, S, or NH; L is alkyl, alkenyl or alkynyl; R2 and R3 are independently selected from the group consisting of H, phenyl, alkyl, aryl, heteroaryl, and a vitamin B6 moiety having one of the structures wherein at least one of R2 and R3 is a vitamin B6 moiety; and R12 is a vitamin B6 moiety having the following structure:and
a pharmaceutically acceptable carrier, diluent, excipient, or a combination thereof. |
