发明名称 |
POLYPEPTIDES DERIVED FROM TRYPTOPHANYL-TRNA-SYNTHETASE AND USES THEREOF IN CONTROLLING OF VASCULARISATION |
摘要 |
FIELD: biotechnology. ^ SUBSTANCE: invention relates to water soluble polypeptides (SEQ ID NO.12) and (SEQ ID NO.7), derived from full-length tryptophanyl-tRNA-synthetase and having angiostatic activity in relation to eye neovasculatisation. Also disclosed are polynucleotides, encoding truncated polypeptide forms (SEQ ID NO.12) and (SEQ ID NO.7), and E.coli cell, expressing abovementioned polypeptides. Said polypeptides are useful in injecting angiostatic composition and kit for inhibiting of eye neovasculatisation. ^ EFFECT: polypeptides having non-immunogenic angiogenic properties. ^ 22 cl, 5 dwg, 2 tbl, 5 ex |
申请公布号 |
RU2297425(C2) |
申请公布日期 |
2007.04.20 |
申请号 |
RU20030128420 |
申请日期 |
2002.02.22 |
申请人 |
DZE SKRIPPS RISERCH INSTIT'JUT |
发明人 |
SHIMMEL' POL;VAKASUGI KEJSUKE;FREHDLEHNDER MARTIN |
分类号 |
C07K14/00;G01N33/50;A61K9/08;A61K38/00;A61K38/16;A61K38/53;A61K48/00;A61P9/00;A61P27/02;C07H21/00;C07K2/00;C12N1/14;C12N1/15;C12N1/19;C12N1/20;C12N1/21;C12N5/00;C12N5/10;C12N9/00;C12N15/09;C12N15/11;C12N15/63;G01N33/15 |
主分类号 |
C07K14/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|