| 摘要 |
The present disclosure provides meroduplex ribonucleic acid molecules (md RNA) capable of decreasing or silencing WNT1, WNT2, or WNT3A gene expression . An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a WNT1, WNT2, or WNT3A mR NA. In addition, the meroduplex may have at least one uridine is a 5-methylu ridine, a nucleoside is a locked nucleic acid, or optionally other modificat ions, and any combination thereof. Also provided are methods of decreasing e xpression of a WNT1, WNT2, or WNT3A gene in a cell or in a subject to treat a WNT1, WNT2, or WNT3A-related disease.
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