| 摘要 |
PURPOSE:An external drug for athlete's foot, obtained by incorporating an antifugal agent 2,4,4'-trichloro-2'-hydroxydiphenyl ether with urea which is a keratin softener, having excellent remedial effect in a short time regardless of the fungal species without recurrence. CONSTITUTION:An external drug for athlete's foot, obtained by incorporating 2,4,4'-trichloro-2'-hydroxydiphenyl ether (trade name; Irgasan, manufactured by Ciba-Geigy Ltd.) with urea. The amount of the Irgasan DP300 to be incorporated in the external drug is 0.2-2wt%, preferably 1.0wt%, and that of the urea is 5- 40wt%, preferably 10wt%. A small amount of sulfuric acid incorporated in the drug stabilizes the composition component and sustains the drug effect. The urea is capable of assisting the swelling and softening of the keratin layer, assisting the permeation of the drug into the deep part of the keratin layer and dissolving and peeling the keratin, promoting the percutaneous absorption of the drug and exterminating trichophytes in the keratin layer by the antifungal agent. |
