NOVEL GENES ENCODING PROTEINS INVOLVED IN MITOTIC CHECKPOINT CONTROL AND METHODS OF USE THEREOF

摘要

Novel human BUB genes and their encoded proteins are provied herein. The kinases encoded by the disclosed BUB1A and BUB1B genes play a pivotal role in mitotic checkpoint control. BUB3 is a substrate of these kinases. BUB genes and their encoded proteins provide valuable therapeutic targets for the design of anti-proliferative agents which inhibit the aberrant cellular proliferation observed in tumor cells.