| 发明名称 |
PROTEINS WITH REPETITIVE BACTERIAL-IG-LIKE (BIG) DOMAINS PRESENT IN LEPTOSPIRA SPECIES |
| 摘要 |
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance. |
| 申请公布号 |
US2016222069(A1) |
申请公布日期 |
2016.08.04 |
| 申请号 |
US201615134168 |
申请日期 |
2016.04.20 |
| 申请人 |
U.S. Government represented by the Department of Veterans Affairs ;The Regents of the University of California ;Cornell Research Foundation, Inc. ;Fundação Oswaldo Cruz - FIOCRUZ |
发明人 |
Ko Albert I.;Reis Mitermayer Galvão;Croda Julio Henrique Rosa;Siqueira Isadora Cristina;Haake David A.;Matsunaga James;Riley Lee W.;Barocchi Michele;Young Tracy Ann |
| 分类号 |
C07K14/20 |
主分类号 |
C07K14/20 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A recombinant expression vector comprising a heterologous polynucleotide molecule encoding a polypeptide comprising an amino acid sequence greater than 90% identical to the amino acid sequence set forth as SEQ ID NO: 10. |
| 地址 |
Washington DC US |
