Devices and methods for high throughput patch clamp assays

摘要

A device for measuring electrophysiological properties of a cell membrane of an individual cell comprises a plate provided with at least one opening. The opening is bounded by a surface and the surface is modified, such as via heat treatment, to facilitate formation of a gigaseal. A chamber is adjacent to the plate. The chamber is in fluid communication with at least one opening and is adapted to hold an electrically conductive solution. The plate further comprises a first electrode located in the chamber and a second electrode located adjacent to the plate.