NOVEL CARBAPENAM ANTIBIOTICS AND THE PREPARATION THEREOF

摘要

1- Ù-methyl-2-(diphenoxyphosphoryloxymethyl)-6- M-(1-allyloxycarbonyloxy-ethyl)-1-caba-2-penem-4-carboxylic acid allyl ester dissolved in acetonitrile anhydride is reacted with sodium iodide which is introduced by dropping for 1 hour at 0 degree Celsius. Thereafter, 1,4,6-triamino-1-methyl-2(1H)-pyrimidinedion dissolved in dimethyl amide is admixed by dropping, reacted at 25 degree Celsius to yield compound represented by general formula(I). In general formula(I), R1 represents 1-hydroxy ethyl, 1-fluoro ethyl, or hydroxy ethyl, R2 represents hydrogen atom, alkyl group having 1 to 4 of carbon atoms or -CH2CH2NHR2, and R3 represents hydrogen atom, alkyl group, alkenyl group or cycloalkyl group.