Protein fusions for the translocation of apo-protein into the periplasmic space

摘要

PCT No. PCT/GB94/00161 Sec. 371 Date Nov. 13, 1995 Sec. 102(e) Date Nov. 13, 1995 PCT Filed Jan. 27, 1994 PCT Pub. No. WO94/17191 PCT Pub. Date Aug. 4, 1994A method of protein synthesis which comprises providing a genetic unit comprising a nucleotide sequence coding for a pre-form apo-protein. The pre-form apo-protein is synthesized in a cytoplasmic region of a cell and translocated to the periplasmic region of the cell for conversion to a corresponding holo-protein.