| 摘要 |
NEW MATERIAL:The compound of formulaI(the group of formula IV is dicarboxylic acid residue; P and Q are 1-3C alkyl, guanidino, etc.; X and Y are O, S or methylene; m and p are 0 or 1; n and q are 1-4) and its acid addition salt. EXAMPLE:N,N'-Bis{3-[3-(1-pyrrolidinylmethyl)-phenoxy]-propyl}-3,4-fura ndicarboxydiamide. USE:It has histamin H2 activity suppressing action, and is useful as a remedy for peptic ulcer, etc. PROCESS:The compound of formulaIwherein Q=R, Y=X, p=m and q=n, (the compound of formulaIa) can be prepared by reacting the amine of formula III with an acylating agent of formula II (R' is reactive residue such as OH, halogen, etc.) in the presence of a base such as triethylaminde, in an inert solvent such as THF, under cooling at -30-0 deg.C. |
