SUBSTITUTED INDOLEPYRIDINIUM AS ANTI-INFECTIVE COMPOUNDS

摘要

The present invention concerns the compounds of formula (1),their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; Ris H, CN, halo, aminoC(=O), C(=O)OH, C-alkyloxy-C(=O), C-alkyl-C(='O), mono- or di(C-alkyl)aminoC(=O), arylaminoC(=O), N-(aryl)-N-(C-alkyl)aminoC(=O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C-alkyl)methanimidamidyl, Hetor Het; Ris H, C-alkyl, C-allkenyl, C-cycloalkyl, wherein said C-alkyl, C-alkenyl and C-cycloalkyl may be optionally substituted; Ris nitro, cyano, amino, halo, hydroxy, C-alkyloxy, hydroxyC(=O), aminoC(=O), C-alkyloxyC(=O), mono- or di(C-alkyl)amino-C(=O), C-alkylC(=O), methanimidamidyl, mono- or di(C-alkyl)methanimidamidyl, N-hydroxy methanimidamidyl or Het; for use as a medicine. The invention further relates to a novel subgroup of the compounds of formula (I), and to compositions comprising compounds of formula (I).