IgA-binding peptide and purification of IgA using the same

摘要

This invention relates to: a peptide which comprises an amino acid sequence consisting of 12 to 18 amino acid residues represented by (X1-3)—C—(X8-10)—C—(X1-3) wherein each X independently represents an arbitrary amino acid residue other than cysteine, and C represents a cysteine residue, and is capable of binding to human IgA; and to a method for analyzing or purifying human IgA using the peptide.

主权项

1. A peptide which consists of any of the following amino acid sequences 1) to 7):
1) QMRCLSYKGRRVCLWL (SEQ ID NO: 2), 2) KRLCLQYKGSKVCFRL (SEQ ID NO: 4), 3) RMRCLTYRGRRVCLEL (SEQ ID NO: 5), 4) SMRCLQYRGSRVCLTL (SEQ ID NO: 6), 5) HLRCLRYKGTRVCFSL (SEQ ID NO: 8), 6) HVRCLSYKGREVCVQL (SEQ ID NO: 9), and 7) PRMCLHYKGRRVCIPY (SEQ ID NO: 10),wherein the peptide is capable of binding to human IgA, andwherein said peptide is optionally labeled, linked to a protein as part of a fusion protein, or bound to a solid phase.