| 摘要 |
Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed. |
| 主权项 |
1. A compound according to Formula (I):or a pharmaceutically acceptable salt thereof, wherein:
each R1 and R2 is independently chosen from hydrogen, C1-6 alkyl, substituted C1-6 alkyl, C1-6 heteroalkyl, substituted C1-6 heteroalkyl, C3-12 cycloalkyl, substituted C3-12 cycloalkyl, C4-12 cycloalkylalkyl, substituted C4-12 cycloalkylalkyl, C6-10 aryl, substituted C6-10 aryl, C7-12 arylalkyl, and substituted C7-12 arylalkyl; or each R1 and R2 together with the nitrogen to which they are bonded independently forms a ring chosen from a C3-12 heterocycloalkyl, substituted C3-12 heterocycloalkyl, C5-10 heteroaryl, and substituted C5-10 heteroaryl; and each X1 is independently chosen from C1-6 alkane-diyl and substituted C1-6 alkane-diyl; wherein each substituent group is independently chosen from halogen, —OH, —CN, —CF3, ═O, —NO2, phenyl, benzyl, —C(O)NR212, —R21, —OR21, —C(O)R21, —C(O)OR21, —NR212, —NR21C(O)R21, and —O(O)R21, wherein each R21 is independently chosen from hydrogen and C1-4 alkyl. |
