VIRUS-LIKE PARTICLE VACCINES

摘要

Dimeric fusion proteins and virus-like particles comprising such dimeric fusion proteins are provided. These dimeric fusion proteins comprise an antigen or antigenic fragment carried between two viral structural proteins or fragements thereof, with or without linkers, in a manner that, relative to traditional monomeric platforms, minimizes steric hindrance among the antigen or antigenic fragment and the viral structural proteins or fragments thereof. This novel design provides for multivalent vaccines and enhanced immunogenicity. Nucleic acids encoding such dimeric fusion proteins and host cells comprising such nucleic acids are also provided. Pharmaceutical compositions comprising the dimeric fusion proteins and/or virus-like particles and methods of prevention or treatment using such compositions are further provided.