发明名称 |
TRIDENTATE CONNEXON AND USE THEREOF |
摘要 |
Disclosed are a type of tridentate linkers and use thereof. The tridentate linkers can be used to prepare an antibody drug conjugates as represented by formula I, wherein, L is an antibody, antibody fragment or protein; T is a tridentate linker part; A is a cleavable linker group or a noncleavable linker part; D is a drug part; n is an integer of 0-8. The structure of the tridentate linker part is as represented by formula II, wherein, W is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or any combination thereof.
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ L -(T-A-D) n €ƒ€ƒ€ƒ€ƒ€ƒ I |
申请公布号 |
EP2949343(A4) |
申请公布日期 |
2016.08.31 |
申请号 |
EP20140743793 |
申请日期 |
2014.01.17 |
申请人 |
NEWBIO THERAPEUTICS INC. |
发明人 |
AN, DEQIANG;HAN, NIANHE;ZENG, DI;YANG, HANG;ZHU, PENG;LI, MINGZHEN;JIAN, LI;YANG, CHUN |
分类号 |
A61K47/48;A61K39/395;A61K45/00;A61P29/00;A61P35/00;A61P37/02;C07D207/448;C07D207/452 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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