| 摘要 |
PROBLEM TO BE SOLVED: To provide a simple LC-MALDI-MS method using separation mode requiring a moving phase containing salt as separation mode of liquid chromatography.SOLUTION: In liquid chromatography - mass spectrometry, a specimen containing an analysis object substance is made to undergo liquid chromatography using a moving phase containing salt to produce an effluent, the produced effluent is made to undergo, without being desalinated, a matrix support laser desorption ionization mass analysis using an organic compound containing a phosphonic acid group as a matrix additive. Thus, LC separation mode in an LC-MALDI-MS method that requires an extremely large constraint in order to avoid ionization suppression by salt is expanded. |
