发明名称 |
PROCESS FOR THE PREPARATION OF FLUTICASONE PROPIONATE FORM 1 |
摘要 |
The invention relates to a novel crystallisation process for preparing fluticasone propionate as crystalline form 1 polymorph with controlled particle size and suitable for micronisation. Said process comprises the step of dissolving fluticasone propionate in acetone or in a mixture of acetone and water and then adding this solution to water or to a mixture of water 10 and acetone, thereby causing fluticasone propionate to crystallise out of the solution as crystalline form |
申请公布号 |
CA2840401(C) |
申请公布日期 |
2016.05.17 |
申请号 |
CA20122840401 |
申请日期 |
2012.07.06 |
申请人 |
PFIZER LIMITED |
发明人 |
TICEHURST, MARTYN DAVID;MARZIANO, IVAN;KOUGOULOS, ELEFTHERIOS |
分类号 |
C07J31/00;A61K9/14;A61K31/56;C30B7/00 |
主分类号 |
C07J31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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