发明名称 |
Pharmaceutical formulations and uses thereof in the treatment of female sexual dysfunction |
摘要 |
The invention relates to the field of female sexual dysfunction. It specifically relates to the influence of the combination of testosterone or an analog thereof and tadalafil on sexual health in female subjects with Female Sexual Dysfunction (such as Female Sexual Arousal Disorder (FSAD) or Female Sexual Desire Disorder (FSDD)). It further relates to the influence of the combination of testosterone or an analog thereof and a compound capable of at least in part inhibiting smooth muscle constriction, for example a compound capable of at least in part inhibiting the adrenergic tone. The invention further discloses other combinatorial therapies in the treatment of Female Sexual Dysfunction. |
申请公布号 |
US9333203(B2) |
申请公布日期 |
2016.05.10 |
申请号 |
US200612084756 |
申请日期 |
2006.11.10 |
申请人 |
EB IP LYBRIDO B.V. |
发明人 |
Tuiten Jan J. A.;Bloemers Johannes M. M. |
分类号 |
A01N45/00;A61K31/56;A61K31/4985;A61K31/519;A61K31/568 |
主分类号 |
A01N45/00 |
代理机构 |
Morrison & Foerster LLP |
代理人 |
Morrison & Foerster LLP |
主权项 |
1. A method for treating female sexual dysfunction, the method comprising:
administering to a female subject in need thereof a combination of tadalafil and testosterone or dihydrotestosterone (DHT), at essentially the same time 3-5.5 hours before anticipated sexual activity, and wherein said testosterone or DHT is provided such that there is a peak concentration of testosterone or DHT in the blood circulation of the subject to whom it has been administered, wherein said testosterone or DHT and tadalafil are formulated to be released upon administration; and said testosterone or DHT is released in one short burst. |
地址 |
Almere NL |