发明名称 |
Coagulation factor VII polypeptides |
摘要 |
The present invention relates to modified human coagulation Factor VII polypeptides having coagulant activity, especially variants having higher proteolytic activity and reduced antithrombin reactivity (increased resistance to inactivation by anti-thrombin) when activated as compared to wild-type FVIIa. The variants have certain substitutions at position T293 of mature human FVII in combination with specifc substitutions at L288, W201 and/or K337. The claims are also directed to pharmaceutical compositions, and medical uses of said factor VII polypeptides. |
申请公布号 |
AU2014336252(A1) |
申请公布日期 |
2016.04.07 |
申请号 |
AU20140336252 |
申请日期 |
2014.10.15 |
申请人 |
NOVO NORDISK HEALTH CARE AG |
发明人 |
OSTERGAARD, HENRIK;GANDHI, PRAFULL S.;OLSEN, OLE HVILSTED |
分类号 |
C12N9/64;A61K38/48 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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