发明名称 RADIOLABELED CATIONIC STEROID ANTIMICROBIALS AND DIAGNOSTIC METHODS
摘要 The disclosure provides compounds, methods, and kits for diagnosis, detection, screening, and imaging of a disease condition (e.g., infection, cancer, tumor, neoplasia), in vitro, ex vivo, and/or in vivo. Certain embodiments include administering a cationic steroid antimicrobial “CSA” or “ceragenin”), the CSA including a steroidal backbone and a heterocyclic ring separated from the steroidal backbone by at least 4 atoms (and up to 24 atoms or more), to a subject having or at risk of having a disease condition in an amount effective to diagnose, detect, screen for or image the disease condition in the subject.
申请公布号 US2016052959(A1) 申请公布日期 2016.02.25
申请号 US201514830356 申请日期 2015.08.19
申请人 Savage Paul B. 发明人 Savage Paul B.
分类号 C07J43/00;G01N33/534;G01N33/58;A61K51/04;C07J51/00 主分类号 C07J43/00
代理机构 代理人
主权项 1. A cationic steroidal antimicrobial (CSA) compound of Formula (I), Formula (II), or salt thereof, having a steroidal backbone, and wherein at least R18 of the steroidal backbone includes a heterocyclic ring spaced apart from the steroidal backbone by at least 4 atoms:
地址 Mapleton UT US