Nanoemulsion therapeutic compositions and methods of using the same

摘要

The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same. In particular, nanoemulsion compositions are described herein that find use in the treatment and/or prevention of infection (e.g., respiratory infection (e.g., associated with cystic fibrosis)), in burn wound management, and in immunogenic compositions (e.g., comprising a Burkholderia antigen) that generate an effective immune response (e.g., against a bacterial species of the genus Burkholderia) in a subject administered the immunogenic composition. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.

主权项

1. A method of treating an infection of a wound comprising administering a composition comprising a therapeutically effective amount of a nanoemulsion, wherein the nanoemulsion comprises:
1. 30-90%, 60-80%, or 60-70% by volume oil; 2. 3-15% by volume solvent; wherein said solvent is selected from the group consisting of ethanol and glycerol; 3. 0.05-10.0% by volume non-ionic surfactant and 0.001-5.0% by volume cationic surfactant; 4. ethylenediaminetetraacetic acid (EDTA); and 5. waterto said wound, wherein said composition kills or inhibits growth of bacteria within the wound infection in the absence of increased inflammation and edema at the site of the wound.