发明名称 |
METHODS OF PREDICTING RESPONSE TO TREATMENT WITH ANTI-TNFα BIOLOGICAL INHIBITORS |
摘要 |
Provided herein are methods for predicting a response to anti-TNFα biologic treatment in patients suffering from rheumatoid arthritis (RA). The methods can be used to discriminate or categorize patients as likely to respond to a monoclonal antibody-based anti- TNFα biological inhibitor, but not likely to respond to an antibody fragment-based anti-TNFα biological inhibitor or a TNF receptor-based biological inhibitor. Alternatively, the methods are also useful to determine whether patients with RA are likely to respond to an antibody fragment-based anti-TNFα biological inhibitor or a TNF receptor-based biological inhibitor, but not likely to respond to a monoclonal antibody-based anti-TNFα biological inhibitor. Also provided are methods for treating a patient with RA based on the patient's level of rheumatoid factor (RF) and/or anti-cyclic citrullinated peptide autoantibody (ACPA) relative to reference control levels. |
申请公布号 |
WO2016016871(A1) |
申请公布日期 |
2016.02.04 |
申请号 |
WO2015IB55840 |
申请日期 |
2015.07.31 |
申请人 |
FUNDACIÓ HOSPITAL UNIVERSITARI VALL D’HEBRON-INSTITUT DE RECERCA |
发明人 |
BARRIL, SARA MARSAL;CANO, ANTONIO JULIA |
分类号 |
G01N33/564 |
主分类号 |
G01N33/564 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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