发明名称 |
Heterocyclic compound and use thereof |
摘要 |
Compounds represented by the formulas;
wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like. |
申请公布号 |
US9221836(B2) |
申请公布日期 |
2015.12.29 |
申请号 |
US201514665237 |
申请日期 |
2015.03.23 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
Kuroita Takanobu;Imaeda Yasuhiro;Iwanaga Kouichi;Taya Naohiro;Tokuhara Hidekazu |
分类号 |
A61K31/445;C07D401/12;C07D495/04;C07D233/90;C07D401/14;C07D407/12;C07D409/06;C07D409/14;C07D413/06;C07D413/14;C07D417/06;C07D417/12;C07D471/04;C07D487/04;C07D487/08;C07D405/14 |
主分类号 |
A61K31/445 |
代理机构 |
Wenderoth, Lind & Ponack, L.L.P. |
代理人 |
Wenderoth, Lind & Ponack, L.L.P. |
主权项 |
1. A compound represented by the formula (I): wherein R1 is a hydrogen atom, an alkyl group optionally having substituent(s), an alkenyl group optionally having substituent(s) or a cycloalkyl group optionally having substituent(s); R2 is (1) a C1-6 alkyl group optionally having 1 to 3 substituents selected from the group consisting of
(a) a hydroxyl group,(b) a halogen atom,(c) a C1-6 alkoxy group,(d) a C1-6 alkyl-carbonyloxy group, and(e) a C3-10 cycloalkyl group, (2) a carboxy group, (3) a C1-6 alkoxy-carbonyl group, (4) a C1-6 alkyl-carbonyl group, or (5) a group represented by the formula: —CO—NR′R″ wherein R′ and R″ are each a hydrogen atom; X is (1) a hydrogen atom; (2) a C1-6 alkyl group optionally substituted by 1 to 3 substituents selected from the group consisting of
(a) a halogen atom,(b) a hydroxyl group,(c) a C1-6 alkoxy group optionally having a C1-6 alkoxy group or a halogen atom,(d) a C1-6 alkylthio group,(e) an aryl group,(f) an aryloxy group optionally having a C1-6 alkoxy group or a halogen atom, and(g) a heteroaryl group; or (3) a C3-10 cycloalkyl group; and ring A is benzimidazole, or a salt thereof. |
地址 |
Osaka JP |