BTNL9 Proteins, Nucleic Acids, and Antibodies and Uses Thereof

摘要

The invention provides novel BTNL9 proteins, including multimers, fragments, and variants of a human BTNL9 protein. In addition, antibodies that can bind to BTNL9 proteins and nucleic acids encoding BTNL9 proteins are provided. Uses for BTNL9 proteins, and agonists or antagonists thereof, are described.

主权项

1. An isolated soluble BTNL9 protein comprising
(a) a polypeptide having an amino acid sequence at least 90% identical to amino acids 35-257 of SEQ ID NO:2, and (b) a second polypeptide having an amino acid sequence at least 90% identical to amino acids 35-257 of SEQ ID NO:2, wherein the alignment window of the amino acid sequences of the polypeptides of (a) and (b) with amino acids 35-257 of SEQ ID NO:2 is at least 80 amino acids long, wherein BTNL9 protein has a molecular weight greater than about three times as large as that of a polypeptide of (a), and wherein the BTNL9 protein can inhibit the proliferation of a T cell stimulated by an anti-CD3 antibody.