发明名称 |
Use of Post-Transplant Cyclophosphamide Treated Allogeneic Marrow Infiltrating Lymphocytes to Augment Anti-Tumor Immunity |
摘要 |
The present invention relates to the field of cancer therapy. More specifically, the present invention provides methods and compositions useful for augmenting anti-tumor immunity. In one embodiment, a method for treating or preventing post-allogeneic transplant relapse in a subject who has received post-transplant cyclophosphamide treatment comprises the steps of (a) obtaining a bone marrow sample from the subject; (b) expanding the marrow infiltrating lymphocytes (MILs) present in the sample; and (c) administering the MILs to the subject. In a specific embodiment, the method significantly reduces the likelihood of developing GVHD. |
申请公布号 |
US2015320798(A1) |
申请公布日期 |
2015.11.12 |
申请号 |
US201314647358 |
申请日期 |
2013.11.26 |
申请人 |
The Johns Hopkins University |
发明人 |
Borrello Ivan M.;Noonan Kimberly A.;Luznik Leonido |
分类号 |
A61K35/17;A61K31/675 |
主分类号 |
A61K35/17 |
代理机构 |
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代理人 |
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主权项 |
1. A method for treating or preventing post-allogeneic transplant relapse in a subject who has received post-transplant cyclophosphamide treatment comprising the steps of:
a. obtaining a bone marrow sample from the subject; b. expanding the marrow infiltrating lymphocytes (MILs) present in the sample; and c. administering the MILs to the subject. |
地址 |
Baltimore MD US |