Systems and methods for delivery of peritoneal dialysis (PD) solutions

摘要

The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments.

主权项

1. A vessel for storing peritoneal dialysis (PD) solutions, comprising:
a first compartment containing a first PD agent, a second compartment containing a second PD agent, the second compartment being in any of direct and indirect fluid coupling with the first compartment, at least one of the first and second compartments being adapted to be manipulated at least partially independently of the other of said first and second compartments, a first seal preventing fluid transfer between the first compartment and the second compartment, and a second seal preventing fluid transfer between the second compartment and an outlet fluid pathway of the vessel, the vessel adapted to inhibit breaking of the second seal prior to breaking of the first seal, the vessel being configured so that the first seal breaks before the second seal breaks, and wherein at least two distinct manipulations are required to break the first and second seals.