发明名称 |
Scaffold-kinase interaction blockades and uses thereof in treating cancer |
摘要 |
Aspects of the invention include compositions and methods for inhibiting the interaction between scaffold proteins and kinases. These compositions and methods find a number of uses including, for example, suppressing tumor growth and metastasis and reducing tumor size and number in a mammal with cancer. |
申请公布号 |
US9155774(B2) |
申请公布日期 |
2015.10.13 |
申请号 |
US201214123953 |
申请日期 |
2012.04.05 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
Jameson Katherine LaRoque;Khavari Paul A. |
分类号 |
A61K38/00;A61K38/17;C07K14/47 |
主分类号 |
A61K38/00 |
代理机构 |
Bozicevic, Field & Francis LLP |
代理人 |
Bozicevic, Field & Francis LLP ;Sherwood Pamela J. |
主权项 |
1. A method of inhibiting RAS pathway activity in a cell, the method comprising:
adding to a cell in vitro an effective amount of an IQ motif containing GTPase activating protein I (IQGAP1) scaffold-kinase interaction blockade (SKIB) agent to block the interaction of a scaffold protein and a kinase thereby inhibiting RAS pathway activity in the cell, wherein the SKIB agent is an isolated IQGAP1 WW peptide or a nucleic acid encoding an isolated IQGAP1 WW peptide, wherein the IQGAP1 WW peptide consists essentially of the WW domain of IQGAP1. |
地址 |
Stanford CA US |