SUBSTITUTED PYRAZOLINE COMPOUNDS: METHODS FOR THEIR PREPARATION

摘要

Methods for obtaining the substituted pyrazoline compounds of general formula (Ia) as well as the intermediates of general formula (III) to this compound. Thus 5-(R¹⁰,R¹¹,R¹²-phenyl)-1-(R¹³,R¹⁴,R¹⁵-phenyl)-N-(piperidin-1-yl)-4,5-dihydro-1H- pyrazole-3-carboxamide (II) can be obtained by the reaction of an activated carbonyl compound derived from 5-(R¹⁰,R¹¹,R¹²-phenyl)-1-(R¹³,R¹⁴,R¹⁵-phenyl)-4,5-dihydro- 1H-pyrazole-3-carboxylic acid (IIIa) with N-aminopiperidine in the presence or absence of an acid acceptor or suitable condensing agent.