MOUSE MODELS CARRYING A KNOCK-OUT MUTATION OF THE GLUTAMINYL CYCLASE GENE

摘要

The present invention provides a knock-out non-human animal, in particular a mouse carrying a glutaminyl cyclase (EC 2.3.2.5) knock-out mutation. The present invention additionally provides the respective cells and cell lines and methods and compositions for evaluating agents that affect Qpct, for use in compositions for the treatment of Qpct-related diseases.