TTP/MRP14 double knock out mouse model of psoriasis

摘要

The present invention provides a non-human transgenic double knockout animal, in which the following genes are knocked out, gene encoding Tristetraprolin (TTP) and gene encoding myeloid-related protein-14 (MRP14; S100A9). In particular the present invention relates to an animal model for psoriasis, psoriatic arthritis, psoriasis-like diseases and inflammatory diseases of the bowel.