| 发明名称 |
TATk-CDKL5 FUSION PROTEINS, COMPOSITIONS, FORMULATIONS, AND USE THEREOF |
| 摘要 |
Disclosed herein are compositions and formulations containing a TATk-CDKL5 fusion protein. Also disclosed are methods of producing a TATk-CDKL5 fusion protein from vectors containing a TATk-CDKL5 cDNA and methods of transducing cells with the vectors containing a TATk-CDKL5 cDNA and the TATk-CDKL5 fusion protein |
| 申请公布号 |
US2015247134(A1) |
申请公布日期 |
2015.09.03 |
| 申请号 |
US201514633757 |
申请日期 |
2015.02.27 |
| 申请人 |
Università di Bologna |
发明人 |
Ciani Elisabetta;Laccone Franco |
| 分类号 |
C12N9/12 |
主分类号 |
C12N9/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A fusion protein comprising:
a CDKL5 polypeptide sequence, wherein the CDKL5 polypeptide sequence has about 50% to 100% sequence identity to SEQ ID NO:2 or SEQ ID NO: 16; and a TATk polypeptide sequence, wherein the TATk polypeptide sequence has about 90% to about 100% sequence identity to SEQ ID NO: 4, wherein the TATk polypeptide is operatively coupled to the CDKL5 polypeptide. |
| 地址 |
Bologna IT |
