发明名称 |
Epinephrine formulations |
摘要 |
Pharmaceutical compositions comprising epinephrine, methods of administration, and methods of making the same. Compositions may comprise at least one of an active agent, a pH raising agent, an antioxidant, a transition metal complexing agent, a pH lowering agent, a tonicity regulating agent, optionally a preservative, and optionally a solvent. |
申请公布号 |
US9119876(B1) |
申请公布日期 |
2015.09.01 |
申请号 |
US201514657990 |
申请日期 |
2015.03.13 |
申请人 |
PAR PHARMACEUTICAL, INC. |
发明人 |
Kannan Vinayagam;Irish Patrick;Bergren Michael |
分类号 |
A01N33/02;A61K31/135;A61K47/02;A61K31/137;A61K47/12;A61K47/18;A61K47/10 |
主分类号 |
A01N33/02 |
代理机构 |
Arent Fox LLP |
代理人 |
Arent Fox LLP |
主权项 |
1. A composition comprising:
in the range of about 0.5 to 1.5 mg/mL of epinephrine and/or salts thereof, in the range of about 6 to 8 mg/mL of a tonicity regulating agent, in the range of about 2.8 to 3.8 mg/mL of a pH raising agent, in the range of about 0.1 to 1.1 mg/mL of an antioxidant, in the range of about 0.001 to 0.010 mL/mL of a pH lowering agent, and in the range of about 0.01 to 0.4 mg/mL of a transition metal complexing agent, wherein the antioxidant comprises sodium bisulfite and/or sodium metabisulfite. |
地址 |
Woodcliff Lake NJ US |