SUBSTITUTED FUSED TRICYCLIC COMPOUNDS COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

摘要

The present invention relates to substituted fused tricyclic compounds of formula (I) their tautomers polymorphs stereoisomers prodrugs solvates co crystals pharmaceutically acceptable salts pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by JAK activity.[Formula I should be inserted here]. The compounds of the present invention are useful in the treatment prevention or suppression of diseases and disorders mediated by JAK activity. Such conditions include but not limited to arthritis Alzheimer s disease autoimmune thyroid disorders cancer diabetes leukemia T cell prolymphocytic leukemia lymphoma myleoproliferation disorders lupus multiple myeloma multiple sclerosis osteoarthritis sepsis psoriatic arthritis prostate cancer T cell autoimmune disease inflammatory diseases chronic and acute allograft transplant rejection bone marrow transplant stroke asthma chronic obstructive pulmonary disease allergy bronchitis viral diseases or Type I diabetes complications from diabetes rheumatoid arthritis asthma Crohn s disease dry eye uveitis inflammatory bowel disease organ transplant rejection psoriasis and ulcerative colitis. The present disclosure also relates to process for the preparation of such compounds and to pharmaceutical compositions containing them.