| 发明名称 | Modulators of alpha-synuclein toxicity | ||
| 摘要 | Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity. | ||
| 申请公布号 | US9018003(B2) | 申请公布日期 | 2015.04.28 |
| 申请号 | US200611914167 | 申请日期 | 2006.05.12 |
| 申请人 | Whitehead Institute for Biomedical Research | 发明人 | Lindquist Susan L.;Gitler Aaron D.;Cashikar Anil |
| 分类号 | C12N5/02;A61K38/17;G01N33/68 | 主分类号 | C12N5/02 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A cell comprising a first expression vector encoding alpha synuclein and a second expression vector encoding SIT4. | ||
| 地址 | Cambridge MA US | ||