CATALYTIC OXIDATION OF POLAR MODIFIERS IN CHROMATOGRAPHIC MOBILE PHASES

摘要

The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.

主权项

1. An oxidizer for use in a chromatographic system having a flame-based detector, comprising:
(i) an inlet capable of receiving a mobile phase containing a polar modifier; (ii) a chamber in fluid communication with the inlet port, wherein the chamber has a catalyst capable of oxidizing at least a portion of the polar modifier; and (iii) an outlet in fluid communication with the chamber capable of exiting the mobile phase and oxidized polar modifier from the chamber.