| 发明名称 | Reagent for assaying anti-treponema pallidum antibody | ||
| 摘要 | To provide a reagent for assaying anti-Treponema pallidum antibody which reagent contains a polypeptide antigen and which reagent provides high assay sensitivity and high specificity, and to provide an assay method employing the assay reagent.;The reagent for assaying anti-Treponema pallidum antibody, for use in an assay of anti-Treponema pallidum antibody on the basis of antigen-antibody reaction is characterized in that the reagent contains, as an antigen, a recombinant polypeptide containing at least domain C and domain D of Treponema pallidum 47 kDa antigen but containing no domain A1 of the 47 kDa antigen. | ||
| 申请公布号 | US8969520(B2) | 申请公布日期 | 2015.03.03 |
| 申请号 | US201113638622 | 申请日期 | 2011.03.31 |
| 申请人 | Sekisui Medical Co., Ltd.;Japan-Lamb Inc. | 发明人 | Hara Yasuyuki;Ota Tetsuya;Kawamoto Michiko;Sato Shinya;Iwamoto Shigehisa;Shimaoka Tatsuro;Sudo Shigeo |
| 分类号 | C07K14/20;G01N33/571;G01N33/545;A61K39/02;G01N33/68 | 主分类号 | C07K14/20 |
| 代理机构 | Oblon, McClelland, Maier & Neustadt, L.L.P. | 代理人 | Oblon, McClelland, Maier & Neustadt, L.L.P. |
| 主权项 | 1. A reagent for assaying anti-Treponema pallidum antibody, based on an antigen-antibody reaction, wherein the reagent comprises, as an antigen, a recombinant polypeptide comprising at least domain C and domain D of Treponema pallidum 47 kDa antigen encoded by the nucleic acid comprising SEQ ID NO:34 and lacking domain A1 of the 47 kDa antigen, wherein the domain A1 is formed of amino acids 1-34 of domain A of the Treponema pallidum 47 kDa antigen, wherein the positions of amino acids are counted form the N-terminus of the 47 kDa antigen. | ||
| 地址 | Tokyo JP | ||