Treatment of vascular, autoimmune and inflammatory diseases using low dosages of IMPDH inhibitors

摘要

The disclosure provides methods and compositions for treating a vascular, autoimmune, and/or inflammatory disease, or a condition associated therewith, with a dose of an inosine monophosphate dehydrogenase (IMPDH) inhibitor effective to treat the vascular, autoimmune and/or inflammatory disease, or associated condition but that does not produce immunosuppression sufficient to reduce the risk of allograft rejection. These lower doses of the immunosuppressant avoid the adverse consequences of severe immunosuppression while providing effective treatment of the vascular, autoimmune and/or inflammatory disease.

主权项

1. A method of treating atherosclerosis associated with a vascular, autoimmune and/or inflammatory disease, comprising administering to a human subject in need thereof an effective amount of mycophenolate mofetil (MMF), wherein the amount administered is less than 0.5 g/day.