| 发明名称 |
INHIBITORS OF NEDD8-ACTIVATING ENZYME |
| 摘要 |
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer. |
| 申请公布号 |
US2015011572(A1) |
申请公布日期 |
2015.01.08 |
| 申请号 |
US201414326051 |
申请日期 |
2014.07.08 |
| 申请人 |
Millennium Pharmaceuticals, Inc. |
发明人 |
McCarron Ashley Sue;Sells Todd B.;Stirling Matthew;Stroud Stephen G. |
| 分类号 |
C07D239/47 |
主分类号 |
C07D239/47 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A chemical entity comprising a hydrochloride salt of the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2 methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate or a pharmaceutically acceptable solvate thereof, wherein said chemical entity is substantially crystalline Form II. |
| 地址 |
Cambridge MA US |
