发明名称 AUTOIMMUNE-INDUCED GLUTAMATERGIC RECEPTOR DYSFUNCTION METHODS AND TREATMENTS
摘要 This invention provides a method of enhancing NMDAR-mediated neurotransmission in a disease associated with NMDAR antibody production, said method comprising administering an NMDAR agonist, an alanine-serine-cysteine transporter inhibitor, a D-amino acid oxidase inhibitor, a glycine transport inhibitor or a combination thereof to said subject. This invention also provides a method of mitigating the severity of, mitigating the pathogenesis of, lowering the incidence of or treating a disease associated with NMDAR antibody production, said method comprising administering an agent, which is an NMDAR agonist, an alanine-serine-cysteine transporter inhibitor, a D-amino acid oxidase inhibitor, a glycine transport inhibitor or a combination thereof to said subject.
申请公布号 WO2014191992(A1) 申请公布日期 2014.12.04
申请号 WO2014IL50474 申请日期 2014.05.26
申请人 SARAH HERZOG MEMORIAL HOSPITAL-EZRATH NASHIM 发明人 HERESCO-LEVY, URIEL
分类号 A61K45/06;A61K31/192;A61K31/198;A61K31/496;A61P25/00 主分类号 A61K45/06
代理机构 代理人
主权项
地址