IONIC SILICONE HYDROGELS COMPRISING PHARMACEUTICAL AND/OR NEUTICEUTICAL COMPONENTS AND HAVING IMPROVED HYDROLYTIC STABILITY

摘要

The present invention relates to ionic silicone hydrogel polymers displaying improved thermal stability. More specifically, the present invention relates to a polymer formed from reactive components comprising at least one silicone component and at least one ionic component comprising at least one anionic group. The polymers of the present invention display good thermal stability and desirable protein uptake.

主权项

1. A contact lens formed from reactive components comprising about 0.1 to about 10 mmol/100 gm reactive mixture of at least one anionic component comprising at least one carboxylic acid group and at least one silicone component selected from the group consisting of reactive polydialkylsiloxane selected from compounds of Formula I: where b=2 to 20; one terminal R1 comprises an ethylenically unsaturated moiety, at least one R1 on a terminal silicone not substituted with an ethylenically unsaturated moiety is independently selected from monovalent groups comprising, monovalent alkyl group having 2 to 16 carbon atoms, and the remaining R1 are selected from monovalent alkyl groups having 1 to 16 carbon atoms, wherein said reactive components comprise less than 5 wt % TRIS, are free of linear polysiloxane crosslinkers and wherein said contact lens further comprises at least one pharmaceutical or neutraceutical component.