| 发明名称 | Vaccine for chikungunya virus infection | ||
| 摘要 | The present invention relates to vaccine formulation capable of eliciting protective immune response against Chikungunya virus infection in humans and other mammalian hosts. The immunogenic formulation comprises purified inactivated Chikungunya virus in a stable formulation. Methods of propagation and purification of the virus are discussed. The inactivated virus formulation is non-infectious, immunogenic and elicits protective immune response in mammalian host. The immunogenic composition is formulated for in vivo administration to humans. The invention also discusses the strategy of developing a subunit vaccine using the recombinant viral proteins as antigens for immunization. The recombinant virus antigens that are potentially immunogenic can be used in diagnosing for the presence of the virus. | ||
| 申请公布号 | US8865184(B2) | 申请公布日期 | 2014.10.21 |
| 申请号 | US200712439509 | 申请日期 | 2007.08.31 |
| 申请人 | Bharat Biotech International Limited | 发明人 | Ella Murthy Krishna;Sumathy Kandaswamy;Pydigummala Jaya Sheela;Hegde Nagendra R. |
| 分类号 | A61K39/12;A61K39/00;C12P1/00;C12N5/00;C07K14/005;C12N7/00 | 主分类号 | A61K39/12 |
| 代理机构 | Emerson Thomson Bennett, LLC | 代理人 | Emerson Roger D.;Detorre Peter R.;Emerson Thomson Bennett, LLC |
| 主权项 | 1. An immunogenic composition comprising an isolated Chikungunya virus antigen selected from SEQ ID NO: 5 to SEQ ID NO: 10. | ||
| 地址 | IN | ||