COMPOSITIONS AND METHODS FOR TARGETING NUCLEAR IMPORT SHUTTLES AND TREATING INFLAMMATORY DISORDERS

摘要

The present invention relates to compositions and methods for treating autoimmune, microbial, metabolic, neoplastic, and posttraumatic diseases mediated by inflammation in a subject. Compositions and methods including at least one importin beta-selective nuclear transport modifier (NTM) and/or at least one importin alpha-selective NTM, and/or at least one importin alpha-specific NTM, and/or at least one inhibitor of importin alpha and importin beta complex formation may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease or abrogation of inflammation.

主权项

1. A composition for treating an inflammatory disease or disorder in a subject comprising a pharmaceutically acceptable carrier and at least one importin beta-selective nuclear transport modifier (NTM) comprising an SSHR domain and a cargo that does not bind to any importin alpha, or at least one importin alpha-selective NTM, wherein the at least one importin alpha-selective NTM is a peptide or compound that binds to one or more binding pockets of an importin alpha and that modulates nuclear transport of at least one intracellular protein, in an amount effective for modifying entry of at least one transcription factor into a cell's nucleus and for treating the inflammatory disease or disorder.